Selected Publications

30 selected publications (out of more than 60) by team members

Saraiva C, Talhada D, Rai A, Ferreira R, Ferreira L, Wieloch T, Bernardino L, Ruscher K (2018) MicroRNA-124-loaded nanoparticles protect and increase differentiation of neural stem cells in vitro but do not contribute to stroke outcome. PLOS ONE. In press.

Aday S, Besnier M, Zoldan J, Carreto L, Saif J, Bernardino L, Santos T, Langer R, Emanueli C, Ferreira L (2017) Synthetic microparticles conjugated with VEGF165 improve the survival and function of endothelial progenitor cells via microRNA-17 inhibition. Nature Communications. 8: 747.

Saraiva C, Esteves M, Bernardino L (2017) MicroRNA: basic concepts and implications for regeneration and repair of neurodegenerative diseases. Biochemical Pharmacology. 141:118-131.

Santos T, Ferreira R, Quartin E, Boto C, Saraiva C, Bragança J, Peça J, Rodrigues C, Ferreira L, Bernardino L (2017) Blue light potentiates neurogenesis induced by retinoic acid-loaded responsive nanoparticles. Acta Biomaterialia. 59:293-302.

Ferreira AC, Santos T, Sampaio-Marques B, Novais A, Mesquita S, Ludovico P, Bernardino L, Correia-Neves M, Sousa N, Palha JA, Sousa JC, Marques F (2017) Lipocalin-2 regulates adult neurogenesis and contextual discriminative behaviours. Molecular Psychiatry. May 9. doi: 10.1038/mp.2017.95.

Barata-Antunes S, Cristovão AC, Pires J, Rocha SM, Bernardino L (2017) Dual role of histamine on microglia-induced neurodegeneration.Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease. 1863:764-769.

Rosa AI, Grade S, Santos SD, Bernardino L, Chen TC, Relvas J, Hofman FM, Agasse F (2016) Heterocellular contacts with mouse brain endothelial cells via laminin and α6β1 integrin sustain subventricular zone (SVZ) stem/progenitor cells properties. Frontiers in Cellular Neuroscience 10:284.

Pereira M, Santos T, Bernardino L, Ferreira R (2017) Vascular inter-regulation of inflammation: molecular and cellular targets for CNS therapy. Journal of Neurochemistry 140:692-702.

Saraiva C, Paiva J, Santos T, Ferreira L, Bernardino L (2016) MicroRNA-124 loaded nanoparticles enhance brain repair in Parkinson’s disease. Journal of Controlled Release. 235:291-305.

Rocha SM*, Saraiva T*, Cristóvão AC, Ferreira R, Santos T, Esteves M, Saraiva C, Je G, Cortes L, Valero J, Alves G, Klibanov A, Kim Y-S, Bernardino L (2016) Histamine induces microglia activation and dopaminergic neuronal toxicity via H1 receptor activation. Journal of Neuroinflammation. 13:137.

Saraiva C, Praça C, Ferreira R, Santos T, Ferreira L, Bernardino L (2016) Nanoparticle-mediated brain drug delivery: overcoming blood-brain barrier to treat neurodegenerative diseases. Journal of Controlled Release. 235:34-47.

Ferreira R+, Fonseca MC, Santos T, Sargento-Freitas J, Tjeng R, Paiva F, Castelo-Branco M, Ferreira LS, Bernardino L+ (2016) Retinoic acid-loaded polymeric nanoparticles enhance vascular regulation of neural stem cell survival and differentiation after ischaemia. Nanoscale. 8:8126-37.

Tenreiro MT, Ferreira R, Bernardino L+, Brito MA+ (2016) Cellular response of the blood-brain barrier to injury: Potential biomarkers and therapeutic targets for brain regeneration. Neurobiology of Disease. 91:262-273.

Santos T, Boto C, Saraiva C, Bernardino L+, Ferreira L+ (2016) Nanomedicine approaches to modulate stem cells in brain repair. Trends in Biotechnology. 34:437-9.

Esteves M, Cristovão AC, Saraiva T, Rocha SM, Baltazar G, Ferreira L, Bernardino L (2015) Retinoic acid-loaded polymeric nanoparticles induce neuroprotection in a mouse model for Parkinson’s disease. Frontiers in Aging Neuroscience. 7:20.

Eiriz MF, Valero J, Malva JO, Bernardino L (2014) New insights into the role of histamine in subventricular zone-olfactory bulb neurogenesis. Frontiers in Neuroscience 8:142.

Agasse F, Xapelli S, Christiansen SH, Coronas V, Rosa AI, Sardá-Arroyo L, Santos T, Ferreira R, Schitine C, Bragança J, Bernardino L, Malva JO, Woldbye DPD (2013) Galanin promotes neuronal differentiation in murine subventricular zone cell  Cultures. Stem Cells and Development. 22:1693-708.

Xapelli S, Agasse F, Sardà-Arroyo L, Bernardino L, Santos T, Ribeiro FF, Valero J, Bragança J, Schitine C, de Melo Reis RA, Sebastião AM, Malva JO (2013) Activation of Type 1 Cannabinoid Receptor (CB1R) Promotes Neurogenesis in Murine  Subventricular Zone Cell Cultures. PLoS One. 8:e63529.

Campos FL, Carvalho MM, Cristovão AC, Je G, Baltazar G, Salgado AJ, Kim YS, Sousa N (2013) Rodent models of Parkinson’s disease: beyond the motor symptomatology. Front Behav Neurosci. 7:175.

Cristóvão AC, Barata J, Je G, Kim YS (2013) PKCδ mediates paraquat-induced Nox1 expression in dopaminergic neurons. Biochem Biophys Res Commun. 437:380-5.

Santos T, Ferreira R, Maia J, Agasse F, Xapelli S, Cortes L, Bragança J, Malva JO, Ferreira L+, Bernardino L+ (2012) Polymeric nanoparticles to control the differentiation of neural stem cells in the subventricular zone of the brain. ACS Nano. 6:10463-74.

Ferreira R, Santos T, Gonçalves J, Baltazar G, Ferreira L, Agasse F, Bernardino L (2012) Histamine modulates microglia function. Journal of Neuroinflammation. 9:90.

Cristóvão AC, Guhathakurta S, Bok E, Je G, Yoo SD, Choi DH, Kim YS (2012) NADPH oxidase 1 mediates α-synucleinopathy in Parkinson’s disease. J Neurosci. 32:14465-77.

Choi DH, Cristóvão AC, Guhathakurta S, Lee J, Joh TH, Beal MF, Kim YS (2012) NADPH oxidase 1-mediated oxidative stress leads to dopamine neuron death in Parkinson’s disease. Antioxid Redox Signal. 16:1033-45.

Bernardino L*, Eiriz MF*, Santos T, Xapelli S, Grade S, Rosa AI, Cortes L, Ferreira R, Bragança J, Agasse F, Ferreira L, Malva JO (2012) Histamine stimulates neurogenesis in the rodent subventricular zone. Stem Cells. 30:773-84.

Maia J, Santos T, Aday S, Agasse F, Cortes L, Malva JO, Bernardino L+, Ferreira L+ (2011) Controlling the neuronal differentiation of stem cells by the intracellular delivery of retinoic acid-loaded nanoparticles. ACS Nano. 5:97-106.

Rosa AI, Gonçalves J, Cortes L, Bernardino L, Malva JO, Agasse F (2010) The angiogenic factor angiopoietin-1 is a proneurogenic peptide on subventricular zone stem/progenitor cells. Journal of Neuroscience. 30:4573-4584.

Cristóvão AC, Choi DH, Baltazar G, Beal MF, Kim YS (2009) The role of NADPH oxidase 1-derived reactive oxygen species in paraquat-mediated  dopaminergic cell death. Antioxid Redox Signal. 11:2105-18.

Bernardino L, Agasse F, Silva BA, Ferreira R, Grade S, Malva JO (2008) Tumor Necrosis Factor-alpha modulates survival, proliferation and neuronal differentiation in neonatal subventricular zone cell cultures. Stem Cells. 26:2361-2371.

Agasse F, Bernardino L, Kristiansen H, Christiansen SH, Ferreira R, Silva BA, Grade S, Woldbye DPD, Malva JO (2008) Neuropeptide Y promotes neurogenesis in murine Subventricular Zone. Stem Cells. 26:1636-1645.


*both authors contributed equally;   +co-corresponding authors


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